You cant login on skype, skype stops working
Lync 2010: %UserProfile%\AppData\Local\Microsoft\Communicator\
Lync 2013: %UserProfile%\AppData\Local\Microsoft\Office\15.0\Lync
Skype for Business: %UserProfile%\AppData\Local\Microsoft\Office\16.0\Lync
Rename profile folder make sure Skype for Business/Lync, Outlook and Onedrive are closed down before you rename the folder
Next time you start Skype/Lync it will start creating a new profile folder
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